Cholinesterase Inhibitors for Lewy Body Disorders: A Meta-Analysis
نویسندگان
چکیده
منابع مشابه
Cholinesterase Inhibitors for Lewy Body Disorders: A Meta-Analysis
BACKGROUND We performed a meta-analysis of cholinesterase inhibitors for patients with Lewy body disorders, such as Parkinson's disease, Parkinson's disease dementia, and dementia with Lewy bodies. METHODS The meta-analysis included only randomized controlled trials of cholinesterase inhibitors for Lewy body disorders. RESULTS Seventeen studies (n = 1798) were assessed. Cholinesterase inhib...
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BACKGROUND Mutations in the glucocerebrosidase (GBA) gene have been reported to modify risk for Parkinson disease (PD) and dementia with Lewy bodies (DLB). However, these findings have not been consistently replicated, and most studies have had substantial methodological shortcomings. OBJECTIVE To better assess the role of GBA variants in altering risk for Lewy body disorders. DESIGN Case-c...
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BACKGROUND We performed an updated meta-analysis of randomized controlled trials of combination therapy with cholinesterase inhibitors and memantine in patients with Alzheimer's disease. METHODS We reviewed cognitive function, activities of daily living, behavioral disturbance, global assessment, discontinuation rate, and individual side effects. RESULTS Seven studies (total n=2182) were id...
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BACKGROUND Previous Cochrane reviews have considered the use of cholinesterase inhibitors in both Parkinson's disease with dementia (PDD) and dementia with Lewy bodies (DLB). The clinical features of DLB and PDD have much in common and are distinguished primarily on the basis of whether or not parkinsonism precedes dementia by more than a year. Patients with both conditions have particularly se...
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Cholinergic dysfunction is common to Alzheimer’s dementia and Schizophrenia. The objective of this study is to undertake a systematic review and metaanalysis of the literature on the cognitive and clinical effects of cholinesterase inhibitors administered to patients with schizophrenia and co-morbid Alzheimer’s disease dementia. A literature search of the MEDLINE, CINAHL, PubMed, PsycINFO, EMBA...
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ژورنال
عنوان ژورنال: International Journal of Neuropsychopharmacology
سال: 2015
ISSN: 1461-1457,1469-5111
DOI: 10.1093/ijnp/pyv086